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The two-tailed Wilcoxon matched-pairs signed-rank test was used to perform the comparisons

GLP-1 medications can affect thyroid function, and persistent fatigue may indicate thyroid hormone changes requiring medication adjustment rather than electrolyte-only intervention

Data from clinical trials show that over a 72-week period, 96% of participants taking Mounjaro/Zepbound (on the highest dose) lost 5% or more of their starting body weight

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