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Cons: Not FDA-approved for any indication, and as of an October 2023 FDA action, ineligible for legal compounding for human use, so supply is limited to research-use-only sellers with variable purity and quality control
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They achieve this by regulating the differentiation of nave CD4 + T cells into specific T-helper (Th) subpopulations, such as Th1, Th2, and Th17, via the provision of co-stimulatory signals and the secretion of distinct cytokines (214, 269, 270)
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