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However, losing weight quickly has many health risks, including: 6 Vitamin and mineral deficiencies Muscle loss Malnourishment Decreased metabolism Additionally, using Topamax for weight loss can increase the risk of disordered eating behaviors as well as the risk of developing full-blown eating disorders like anorexia nervosa (AN) and bulimia nervosa (BN)

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What tends to come back is fat, not muscle

The trial also featured a "novel, patient-centric approach to clinical trial design." Placebo participants who regained 50% or more of their weight were eligible for rescue therapy with orforglipron