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While small molecules like nicotine or oestrogen can be absorbed via a patch, GLP-1 molecules are roughly ten times larger than the limit for skin absorption
We spoke with three doctors who specialize in weight loss and prescribe these medications
The STEP clinical trials the largest studies ever conducted on semaglutide, found that nausea typically resolves within the first two weeks, diarrhea clears within days, and even constipation, the most persistent GI side effect, averages around 47 days before it improves
Experimental models show that GLP-1 receptor activation suppresses microglial overactivation and pro-inflammatory cytokine signaling, while restoring diet-induced impairments in brain-derived neurotrophic factor (BDNF) pathways [21]
