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Our patch-clamp electrophysiology results corroborate these findings, demonstrating that GLP-1RAs directly activate DMH GLP-1R neurons, which in turn send inhibitory projections to ARC AgRP/NPY neurons [69]
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It suggests theres an additive effect of these two medications, said Andrew Saxon, an addiction psychiatrist at the University of Washington who was not involved with this study, potentially because liraglutide and buprenorphine target different mechanisms
Its not a clear-cut winner over tirzepatide in head-to-head databut it doesnt need to be
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