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Le Foll, C
In MS models, reactive astrocytes upregulate P2X 7 receptors, driving cytokine release and oligodendrocyte injury [427, 428]
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de novo lipogenesis, along with downregulating enzymes linked to lipid synthesis, such as ACC and FAS ( in vitro experiment demonstrated that GLP-1RA induces the phosphorylation of Akt, PDK-1, and PKC-, which are key proteins involved in the insulin signaling pathway
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