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This study aimed to compare the physiological roles of GIPR in the AP and hypothalamus by targeted regional KO of Gipr , using a floxed Gipr mouse model (Gipr fx/fx ) stereotactically injected with adeno-associated virus (AAV) encoding Cre-recombinase to generate mice with KO of Gipr in either the AP (Gipr AP-KO ) or hypothalamus (Gipr hypo-KO )

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Anxiety-related palpitations (sinus tachycardia): Fast heart rate Regular, steady rhythm like a drumbeat thats sped up Predictable pattern, even if it feels intense Atrial fibrillation (AFib): Heart may feel fast, slow, or fluctuate Irregular, unpredictable rhythm, often described as fluttering, chaotic, or like popcorn popping No steady pattern between beats In simple terms, anxiety usually feels like a fast but steady heart, and AFib often feels like an erratic, uneven heartbeat

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