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Although GSTs are generally viewed as playing a protective role in foreign compound metabolism, they can also catalyze reactions that lead to toxification
So here is the fact
Non-esterified fatty acids (NEFAs) activate the TLR4/NF-B pathway in granulosa cells, increasing NLRP3 and caspase-1 levels, along with the release of IL-1 and IL-6, leading to OS, pyroptosis, and inflammation (Wang Y
In addition, peroxynitrite can modify proteins by nitration or oxidation of amino acids, involving cysteine, tyrosine, and methionine (Bartesaghi and Radi 2018)
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