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Structurally, the BBB is highly lipophilic and composed of cerebrovascular endothelial cells, astrocytes, pericytes, neuronal cells, immune cells, microglial cells, glial cells, smooth muscle cells, and a basement membrane (Fig

Increase frequency of glucose monitoring with changes to: insulin dosage, co-administered glucose lowering medications, meal pattern, physical activity, and in patients with renal or hepatic impairment and hypoglycemia unawareness

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