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Therapeutic interventions to mitigate mitochondrial dysfunction and oxidative stress-induced damage in patients with bipolar disorder
Five DEGs were involved in the biosynthesis of 4 proteins required in the pathway of one-carbon pool by folate, among which the 5-formyltetrahydrofolate cyclo-ligase (MTHFS) has a scavenger role as the only enzyme that converts 5-formyl-THF to 5,10-methenyl-THF [46] and showed a value of log2FC 2.69 at 3 DPI vs CK (Additional file 1: Dataset S1)
In my three decades of direct observation and collaboration with leading clinicians, Ive seen consistent therapeutic responses with once-daily and twice-daily dosing protocols
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