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Examples of such functions include reducing oxidative stress, increasing expression of pro-inflammatory cytokines (24), and improving mitochondrial dysfunction (5) and insulin resistance (IR) (6, 7)
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Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)
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