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The stronger action of retatrutide might work better for them

However, the best results occur when combined with high-protein nutrition (aim for 1g per pound of goal body weight) to preserve muscle mass, resistance training 2 to 4 times per week to maintain strength and metabolism, and adequate sleep and stress management

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(2) Mechanism of Action: stimulation increases heart rate and myocardial contractility, while activation produces bronchodilation and peripheral vasodilation