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Nevertheless, the heterogeneity of study designs, sample sizes, and a paucity of long-term safety data highlight the need for standardized protocols and further high-quality trials

This shows that natural homocysteine levels are a U-shaped curve in regard to all-cause mortality, but if there is an external reason for low homocysteine, such as excess NAC or B6, there is no statistically significant negative effect.[ref] Which brings us to the role of the gut microbiome in both low or high homocysteine

PDEVs have been shown to directly influence macrophage phenotype, shifting the M1 (pro-inflammatory) and M2 (anti-inflammatory) balance