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By activating amylin and calcitonin receptors in the brain, particularly within the hypothalamus and brainstem, Cagrilintide reduces food intake, promotes satiety, and contributes to sustained weight loss

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By binding to receptors on immune cells, VIP suppresses the activity of inflammatory signaling molecules and modulates the behavior of immune cells, including T cells and macrophages (7)

We speculate this could potentially explain the absence of reduced risk for PDAC associated with GLP1RA-related weight loss in contrast to weight loss following bariatric surgery 45