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Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism
Epub 2020/09/06
However, other beta blockers, for example, atenolol and metoprolol, have not been found to be ototoxic
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