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Limitations and perspectives Despite the transformative potential of biologic therapies for modulating lipid metabolism, such as PCSK9 inhibitors for lowering LDL-C and emerging RNA-based agents that target Lp(a) and triglycerides, significant limitations still remain
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A French nationwide case-time-control study of completed suicides and suicide attempts found no specific risk related to prior psychiatric history or obesity during GLP-1 RA use ( 5 State of the art and future directions No clear causal mechanism linking GLP-1 RA use to suicidality has been established
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