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The average fluorescence values of the culture medium background were subtracted from all experimental wells (samples and controls)
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This causes the metabolic rate to decrease, meaning people need to eat fewer calories to maintain the same weight
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The review would benefit from a bit more text on how this notion impacts the balance between desired therapeutic effects, "diluted" effects from dimer-mediated versus non-dimer effects, and undesired off-target effects (which are discussed some in terms of receptor specificity, but not in terms of anatomy, where the same dimer may have different effects in different brain regions). Response: We have added a new section title General treatment approaches before the concluding remarks
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