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Patients frequently report that their worst pain days become more manageable, and the intensity of flare-ups decreases

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Analogs of 2-ketoglutarate such as 2-oxoglutarate, 2-iminoglutarate, 2-methyleneglutarate, 2,4-pyridine dicarboxylate, 3,5-pyrazole carboxylate, and others have been reported to be screened for the inhibition of NADP-GDH from Aspergillus niger

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