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In contrast, LCACs are thought to have the potential to activate inflammation, activating the NF-B luciferase reporter gene in RAW 264.7 cells in an acyl chain length- and concentration-dependent manner, as well as the phosphorylation of JNK and ERK [54, 55]
However, these changes do not translate to a significant displacement of the cytoplasmic region of TM5
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The competitive pipeline: 8 drugs, 4 mechanisms K-Dense Web queried ClinicalTrials.gov API v2 and mapped the entire incretin agonist pipeline by development phase, mechanism class, and administration route
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