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Abnormal ganglionic activity may promote electrical instability and autonomic imbalance, establishing the ICNS as a therapeutic target for neuromodulation and ganglionated plexus ablation ( 2.2 Heart-to-brain pathways Afferent pathways from the heart to the brain originate from chemoreceptors and baroreceptors in the atria, ventricles, the aortic arch, carotid sinus and coronary and pulmonary arteries ( Emerging evidence also suggests that the brain can both perceive and influence the progression of atherosclerotic lesions

Hamashima S, Homma T, Kobayashi S, Ishii N, Kurahashi T, Watanabe R, et al