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The STAT3 factors induce the expression of SOCS proteins which consequently inhibit the function of JAK/STAT3 signaling, i.e., SOCS proteins exert a negative feedback on the JAK/STAT3 signaling induced by both insulin/IGF-1 and certain cytokine pathways

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Proteins were digested into peptides using a high-throughput automated version of the protein aggregation capture workflow 52 on the KingFisher Flex Purification System (Thermo Fisher Scientific)

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