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In order to prevent oxidative stress due to increased intracellular iron and subsequent cell death by ferroptosis, OLs can export iron via FPN that acts in concert with ferroxidases, as evidenced by increased oxidative stress in OLs deficient for hephaestin (54)

NICE guidance specifies use for people with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities) who have been referred to specialist services

The goal is not to suffer through side effects, but to find the dose that produces results while remaining tolerable

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