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While nausea, vomiting, and digestive problems are common side effects, they generally disappear after a brief time
Coffee has mild prokinetic effects and can stimulate colonic contractions
2010;88(Suppl 1):S39
The non-coenzyme action of thiamine in neurotransmission is further supported by the action of the thiamine analog oxythiamine, whose diphosphorylated derivative (oxyThDP), formed by TPK in vivo , is an antagonist of the coenzyme action of thiamine
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