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ROS increase the severity of bronchial asthma by activating numerous inflammatory mediators, including leukotrienes B4 (55) and D4, regulated on activation, normal T-cell expressed and secreted (RANTES) chemokines, eotaxins, IL-5 (55), IL-1, -4, -6, GM-CSF, interferon (INF), platelet-activating factor (PAF), tumor necrosis factor (TNFa), adhesion molecules (VCAM-1) (56) and major basic protein (MBP) (57)

Signs of Vitamin B12 Deficiency Vitamin B12 deficiency can develop gradually, and symptoms may range from mild to more noticeable

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