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National Academy Press, 1989

Clinical translation has been constrained by poor aqueous solubility, limited gastrointestinal absorption, rapid phase II metabolism, and inconsistent formulation quality across investigational preparations limitations extensively documented across pharmacokinetic studies and clinical reviews

The carboxyl-terminal fragment of hGH corresponding to amino acids 177191 (AOD9604) was shown to act as a lipid mobilizing domain with inhibitory action on acetyl-CoA carboxylase (ACC) activity in hepatocytes and adipocytes

Se debe tener cuidado cuando se utiliza junto con suplementos de cobre o tratamientos que afecten el metabolismo del cobre