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Sun R, Du S, Wang M, Chen Z, Yan Q, Yuan B, Jin Y (2024) Colonic long-term retention and colonization of probiotics by double-layer chitosan/tannic acid coating and microsphere embedding for treatment of ulcerative colitis and radiation enteritis

The mechanism of this combined effect appears to be sequential: TB-500 mobilizes and migrates repair cells to the injury site (via actin regulation and chemotactic signaling), while BPC-157 creates the optimal local microenvironment (via angiogenesis, growth factor expression, and NO modulation) for those cells to perform effective repair once they arrive