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This causes the muscles to relax, which creates smoother, firmer skin and softens the appearance of dynamic wrinkles, such as crows feet, forehead wrinkles, and frown lines
When amino acids reach the small intestine, they directly trigger L cells to release GLP-1 through nutrient-sensing mechanisms involving the calcium-sensing receptor (CaSR) and peptide transporter 1 (PEPT1)
GLP-1 medications are not recommended during pregnancy or breastfeeding, and some (like semaglutide) should be discontinued at least 2 months before a planned pregnancy
Injectable formulations carry greater risk
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