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Punicalagin exhibits poor small intestinal bioavailability due to its large molecular weight (1084 Da) and extensive hydrogen bonding capacity (29), which enables it to reach the colon where interaction with gut microbiota occurs
When somebody loses weight whether thats with diet changes, an increase in physical activity, medication or bariatric surgery we know theres a reduction in fat mass, as well as a reduction in muscle mass
What is more, insulin stimulates PDA cells to secret Shh (sonic hedgehog), IL-6, tissue growth factor (TGF) to promote fibroblast cell growth in TAM (Mutgan et al., 2018)
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