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Dehydration triggered by nausea or reduced appetite on GLP-1 therapy can also reduce intervertebral disc hydration, making discs less shock-absorbent

lighter or skipped periods suggest metabolic improvement in PCOS-pattern patients Cycle changes lasting beyond 6 months at stable weight or accompanied by severe pain, flooding, or clotting warrant gynecological evaluation, not just dose adjustment Direct answer (40-60 words) Zepbound (tirzepatide) disrupts menstrual cycles through rapid weight loss releasing stored estrogen from adipose tissue, improved insulin sensitivity changing ovulation patterns in metabolically compromised patients, and direct GLP-1 receptor activation affecting hypothalamic-pituitary-ovarian signaling