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Medical supervision is required for individuals with thyroid conditions, kidney disease, or during pregnancy

For example, a 2020 study gave 202 people with mild mental impairment and low or low-normal B12 levels and elevated homocysteine levels B12 replacement therapy for 3 months ( After the treatment, 84% of the participants reported significant improvements in symptoms, like poor focus, memory decline, and forgetfulness ( Glossitis is a medical term that refers to an inflamed, red, and painful tongue

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Data from the 2021 Nature Aging paper are particularly illuminating on this point