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Wegovy mimics a single hunger hormone called GLP-1, whilst Mounjaro mimics two hormones: GLP-1 and GIP
Lilly also committed an additional US$4.5 billion across Indiana manufacturing sites, with the company stating that planned production includes Foundayo, Zepbound, Mounjaro and retatrutide-related capacity, highlighting how manufacturing scale has become central to GLP-1 market leadership
In TRIUMPH-4 (obesity + knee OA): nausea 43%, diarrhea 33%, vomiting 21%, constipation 25%, dysesthesia 20.9%
GLP-1 receptors are densely distributed throughout the gastrointestinal tract, and when activated by these medications, they affect multiple aspects of digestive function
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