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It can cross the BBB and influence pituitary release of gonadotropins, thereby affecting hormone levels
10.1136/gut.52.10.1472 102 ShimaN.NagaoM.OgakiF.TsudaE.MurakamiA.HigashioK
Consistently, TRPV1 is also found to be expressed by the murine enteroendocrine cell line model STC-1 and its agonism induces the release of GLP-1 in vivo (377)
It is released after eating and plays a critical role in regulating: Blood sugar levels Insulin secretion Appetite signaling Digestion speed Inflammatory responses GLP-1 communicates directly with the brain, pancreas, heart, and immune system, making it far more than just an "appetite hormone." When GLP-1 binds to its receptors, it helps the body respond to food more efficiently and maintain metabolic balance
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