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Metabolic Flux Adaptations During GLP-1 Receptor Agonist Therapy: Redox Implications
Aminesincluding arginine, proline, and methionine sulfoxidewere upregulated while serotonin and sarcosine were downregulated, suggesting an SSRI effect on urea cycle, one-carbon metabolism, and serotonin uptake
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Second, it enables researchers and practitioners to identify individual tolerance thresholds before reaching maximum doses
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