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In toxin-induced PD mouse models, DA-JC1, a novel dual GLP-1/GIP receptor agonist, improved motor impairment, increased the number of dopaminergic neurons in the substantia nigra, enhanced BDNF levels, and modulated apoptosis signaling pathways by altering the expression of Bax and Bcl-2 [89, 90]
Mounjaro contains tirzepatide , a medication that works on both GLP-1 and GIP receptors involved in appetite regulation, digestion, blood sugar control, and metabolism
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