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It has also been suggested that DPP-4 might be secreted into the interstitial spaces within the islets (100) and, accordingly, DPP-4 activity can be measured in the media of human islet incubations (101), but whether this is simple shedding of membrane-associated DPP-4 or regulated secretion is not known

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When L-carnitine is deficient, fat accumulation can occur