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Granhall C, Donsmark M, Blicher TM et al (2019) Safety and pharmacokinetics of single and multiple ascending doses of the novel oral human GLP-1 analogue, oral semaglutide, in healthy subjects and subjects with type 2 diabetes

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Both of these peptides are known to have high affinity binding to the -opioid receptors, MORs

E 2 -3,4-Q can be converted back to 4-OHE 2 in a single step by quinone reductase, or in two sequential steps catalysed by P450 reductase via the semiquinone intermediate