Extensive evidence demonstrates that PI3K/Akt is a central regulator of cardiomyocyte function and survival, involving multiple aspects of inflammatory regulation, apoptosis, oxidative stress, and cardiac hypertrophy, and it plays an important regulatory role in the progression of cardiovascular disease (Cheng et al., 2021
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Apart from lifestyle changes, there is increasing interest in using medication to help people lose weight and reduce cardiometabolic complications
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