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These findings led to changes in clinical practice guidelines modern diabetes guidelines recommend GLP-1 agonists (or related drugs) for patients with type 2 diabetes who have cardiovascular risk, and even suggest using a GLP-1 RA prior to insulin in many cases due to their multiple benefits and weight loss advantage ( [10] ) ( [11] )

They also impact the brain, particularly the hypothalamus, the area that controls hunger, by activating appetite-suppressing neurons, she says

Dehydration worsens nausea and is easy to overlook when your appetite is suppressed

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