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We thereby speculate that such cells undergo negative selection initially, but over time may result in a select subpopulation of cells accruing mutations that can overcome p53-mediated apoptosis and cell cycle blockade and ultimately expand
doi: 10.7554/eLife.76183 71 CruzatVMacedo RogeroMNoel KeaneKCuriRNewsholmeP
Lv S, Sylvestre M, Prossnitz AN, Yang LF, Pun SH
The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)
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