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Recent studies suggest that treatment with semaglutide (GLP-1RA) in combination with firsocostat (ACC-a inhibitor) and/or cilofexor (nonsteroidal FXR agonist) can further improve hepatic steatosis and thus NAFLD compared with semaglutide alone in exploratory efficacy analyses [113]
This is precisely the mechanism that contributes to the lean mass losses observed in GLP-1 clinical trials
Mller TD, Clemmensen C, Finan B, et al
Kelner, M.J., Bagnell, R.D., Uglik, S.F., Montoya, M.A
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