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Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, and Semaglutide, a GLP-1 RA, have shown greater weight loss efficacy than traditional medications like Phentermine/Topiramate (Qsymia), Naltrexone/Bupropion (Contrave), and Phentermine 12,14,15
TRIUMPH-4 did show improvements in several cardiovascular risk markers: reductions in non-HDL cholesterol, triglycerides, high-sensitivity C-reactive protein (hsCRP), and systolic blood pressure
If confirmed, this could redefine therapeutic strategies for metabolic diseasetargeting the inflamed hypothalamus as the origin rather than the consequence of systemic dysfunction
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