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Plasma stability of the parent nonapeptide is short
Elderly Individuals : The stomach acid formation decreases with age and stomach acid is necessary for the intake of vitamin B12 from the diet
DSS-induced colitis in mice elicited pronounced symptoms, including reduced locomotor activity, decreased consumption of food and water, dull and lifeless fur, signs of depression-like behavior, huddling behavior, perianal swelling and congestion, diarrhea, bloody stools, and substantial weight loss
(Frontiers in Pharmacology, 2022) reported pharmacokinetics and tissue distribution in rats and dogs, including a rapid plasma half-life under 30 minutes after IM or IV dosing
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