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Through these investigations, we aim to explore how GRN deficiency differentially impacts lipid metabolism across cell types, brain regions, and model systems
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The early cancer therapies referred to antimetabolites, such as methotrexate (a folate analog) and 5-FU (a pyrimidine analog), that competitively inhibit key metabolic enzymes (e.g., dihydrofolate reductase and thymidylate synthase) in in vivo , thereby affecting or antagonizing cancer cell metabolism and proliferation (Lukey et al., 2017)
The Lancet Diabetes & Endocrinology , 6(4), 275-286
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