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Gastroenterology 155, 458468
Glutathione is present in millimolar concentrations in most mammalian cells and it is involved in several fundamental biological functions, including free radical scavenging, detoxification of xenobiotics and carcinogens, redox reactions, biosynthesis of DNA, proteins and leukotrienes, as well as neurotransmission/neuromodulation
Furthermore, because lipid peroxidation in cells is regulated by the content and position of polyunsaturated fatty acids (PUFAs), it indirectly determines the degree of ferroptosis (19)
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