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Compound-Specific Considerations Berberine Products Effective berberine supplementation requires 500mg doses taken 2-3 times daily with mealstotal daily intake of 1,000-1,500mg

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It concluded that both oral glutathione at 500 mg/day and topical 2% oxidised glutathione reduced melanin index in sun-exposed skin but effects were limited to sun-exposed areas and showed variability between trials

Sandalio LM, Collado-Arenal AM, Romero-Puertas MC