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To further validate the above discovery, the authors designed two structurally similar fentanyl derivatives FBD1 (partial agonist) and FBD3 (full agonist), with the aim to obtain OR agonists with reduced/abolished -arrestin signaling but relatively intact G protein activity (Figure 6a)
This result may be related to insufficient sample size (Rizza et al., 2023)
The Triple Threat A new player on the horizon is retatrutide, known as a GIP/GLP-1/glucagon receptor triple agonist
Data on circRNAs in CaP progression and AR function are relatively new and still accumulating
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