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A vast evidence supports the occurrence of reactions of metal ions with H 2 O 2 , and hydroperoxides in the cytosol and in biological membranes
The rash is usually maculopapular, but lesions are polymorphous and can present as plaques, blisters, target-like lesions, urticaria, exfoliation, eczema, or, rarely, lichenoid eruptions (Figure 2)
157187 (John Wiley & Sons, 2008)
Type-I IFN: Type-I IFN facilitates dendritic cell (DC) maturation, enhances autoimmune T cell survival, and activates autoantibody-producing B cells, primarily through sustained IFN- production, autophosphorylation, and activation of the IFN- receptor (IFNAR)-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) (87, 88)
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