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Factors Indicating Need for Dose Escalation Increase doses when minimal subjective improvements after 3-4 weeks at current dose, IGF-1 levels show minimal or no meaningful increase from baseline after an adequate trial period (e.g., 812 weeks), good tolerance without significant side effects suggesting room for higher dosing, and treatment goals require more aggressive approach than current dose provides

The saturation dose is the point where adding more peptide is unlikely to add much more GH response, and food near the injection window can blunt the pulse

Clinical data show 5-7% weight loss in about 6 months

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