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Another study a meta-analysis and review of 78 trials involving more than 73,000 participants concluded that semaglutide was associated with an increased incidence of NAION but emphasized that evidence for a causal link remains inconclusive
Other companies are developing similar or even more potent drugs (for example, tirzepatide , which activates GLP-1 and a second hormone GIP, was approved for diabetes in 2022 and for obesity in 2023 after showing even greater weight loss)
Caccuri AM, Antonini G, Nicotra M, Battistoni A, Lo Bello M, Board PG
Tirzepatide produces greater weight loss (20-22%) compared to semaglutide (15-17%) based on clinical trial data
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