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Townsend DM, Manevich Y, He L et al (2008) Novel role for glutathione S-transferase
Results: Depleting Smo in hepatocytes increased markers of DNA damage (8OHDG, H2AX) and senescence (p16, p21), and exacerbated the effects of CDAA-HFD, increasing markers of steatosis (Oil-red O), lipotoxicity (4-HNE), and fibrosis (-SMA, Sirius red)
Alongside these pathways it influences growth-factor signalling, collagen synthesis and fibroblast activity, the building blocks of soft-tissue repair
IM B12 injection is especially appropriate when oral supplementation has been inadequate, when absorption is compromised, or when neurological symptoms are present (Stabler, New England Journal of Medicine , 2013)
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